Miyoshi_Frontmatter_O.pdf	2
	Miyoshi_Ch01_O.pdf	16
	Part I: Clinical Manifestations of Neuropsychiatric Disorders	17
	Introduction	17
	Neuropsychiatric Symptoms and Neuropsychiatric Disorders	18
	Characteristics of Clinical Manifestations of Neuropsychiatric Disorders	19
	Multiple Neuropsychiatric Symptoms Occur Simultaneously	19
	Probable and Possible Symptoms of Neuropsychiatric Disorders	20
	Neuropsychiatric Symptoms Could Be the Earliest Symptomsin Cerebral Disorders	21
	Neuropsychiatric Symptoms Are Not Pathognomonic to a Certain Cerebral Disorder	22
	Neuropsychiatric Symptoms May Mimic Endogenous Psychoses	22
	Neuropsychiatric Symptoms and Syndromes	22
	Anxiety and Neurotic Complaints	24
	Apathy	24
	Mood Disorder	24
	Hallucinations and Delusions	25
	Behavioral and Personality Changes	26
	Delirium	26
	Persistent Cognitive Impairment (Dementia)	26
	Dementia of the Alzheimer Type	27
	Neurodegenerative Dementias of Non-Alzheimer Type	27
	Vascular Cognitive Impairment	28
	Conclusions	28
	References	29
	Miyoshi_Ch02_O.pdf	30
	Thyroid–Brain Interactions in Neuropsychiatric Disorders	31
	Introduction	32
	Thyroid Axis Hormone Secretion and Metabolism	32
	Thyroid Hormone Transport to the Brain	33
	Thyroid Hormone Receptors and Homeostasis in the Brain	33
	Fetal Thyroid Economy and Development of the Brain	35
	MCT-8 Mutations and Neurodevelopment	36
	Hypothyroidism and Mental Function in Adults	36
	Treatment of Hypothyroidism	37
	Hyperthyroidism and Mental Symptoms in Adults	37
	Treatment of Hyperthyroidism	38
	Low T3 Syndrome in Mental Disorders	38
	Thyroid Autoimmunity and Mood Disorders	38
	Thyroid Function in Mood Disorders	39
	Thyroid Abnormalities and Schizophrenia	39
	Thyroid Axis Hormones in Treatment of Mental Disorders	40
	Thyroid Hormones	40
	Thyrotropin-Releasing Hormone	40
	Conclusion	41
	References	41
	Miyoshi_Ch03_O.pdf	45
	Lack of Insight and Awareness in Schizophrenia and Neuropsychiatric Disorders	45
	Introduction	46
	Insight into Psychiatric Disorders (Schizophrenia)	46
	Awareness and Symptomatology	47
	Clinical and Demographic Factors	47
	Awareness and Neurocognition	48
	Neuroimaging	48
	Mood	49
	Insight and Awareness in Alzheimer’s Disease	49
	Insight and Awareness in Brain Injury	50
	Direct Comparison of Insight and Awareness in Patients with Schizophrenia, AD, and Brain Injury	51
	Participants	52
	Methods	53
	Results	53
	Between-Group Contrasts	53
	Pooled Patient Analysis	55
	Summary and Conclusions	56
	References	56
	Miyoshi_Ch04_O.pdf	62
	Visual Hallucinations in Neurodegenerative Disorders	62
	Introduction	62
	Visual Hallucinations in Synucleinopathies	63
	Dementia with Lewy Bodies	63
	Epidemiology	63
	Factors Associated with VH in DLB	64
	Clinical Characteristics of VH in DLB	64
	Clinical Impact and Treatment of VH in DLB	65
	Parkinson’s Disease	65
	Epidemiology	65
	Factors Associated with the Presentation of Hallucinations in PD	65
	Clinical Characteristics of VH in PD	66
	Clinical Impact and Treatment of VH in PD	66
	Multiple System Atrophy	67
	VH in Tauopathies	67
	Alzheimer’s Disease	67
	Epidemiology	67
	Factors Associated with the Presentation of Hallucinations in AD	68
	Clinical Characteristics of VH in AD	68
	Clinical Impact and Treatment of VH in AD	68
	Progressive Supranuclear Palsy	68
	Frontotemporal Dementia	69
	VH in Heredodegenerative and Other Neurodegenerative Diseases	69
	Conclusions	70
	References	70
	Miyoshi_Ch05_O.pdf	75
	Organic Delusional Syndrome: Tentative Neuropsychological Mechanism of Delusions	75
	Introduction	76
	Persecutory Delusion and Delusional Perception in PDFTBI	76
	Delusional Misidentification Syndrome: Capgras Syndrome	80
	Anosognosia and Somatoparaphrenia	82
	Conclusion	84
	References	85
	Miyoshi_Ch06_O.pdf	87
	Neurological and Psychological Formsof Amnesia	87
	Introduction	87
	Transient Neurological Amnesias	89
	Transient Global Amnesia	89
	Transient Epileptic Amnesia	90
	Persistent Neurological Memory Disorders	91
	The Korsakoff Syndrome	91
	Herpes Encephalitis	93
	Confabulation	94
	Transient Psychogenic Amnesia	95
	Psychogenic Fugue	95
	Situation-Specific Amnesia	96
	Persistent Psychogenic Amnesia	97
	Conclusions	98
	References	98
	Miyoshi_Ch07_O.pdf	102
	The Neuropsychological Aspect of Epilepsy	103
	Discussion and Conclusion	107
	References	108
	Miyoshi_Ch08_O.pdf	110
	The Interictal Dysphoric Disorder of Epilepsy	110
	Epilepsy and Depression: An Overview	110
	Is Depression Associated with Any Specific Epilepsy Syndrome?	112
	Is There a Mood Disorder Specific of Epilepsy? The Interictal Dysphoric Disorder	112
	Diagnosing Mood Disorders in Patients with Epilepsy	115
	Conclusions	117
	References	117
	Miyoshi_Ch09_O.pdf	120
	Neuropsychiatric Symptoms of Seizure Disorders with Special Reference to the Amygdala	120
	Introduction	120
	The Amygdala	121
	The Amygdala in Epilepsy	122
	Structural Changes	123
	Functional Studies	125
	Conclusions	126
	References	127
	Miyoshi_Ch10_O.pdf	129
	Neuropsychiatric Assessment of Traumatic Brain Injury During Acute Neurorehabilitation*	130
	Introduction	131
	Defining TBI	132
	Characterizing TBI Severity	133
	Neurobiology of TBI	134
	Brain–Behavior Relationships and TBI	136
	Posttraumatic Encephalopathy	137
	Neuropsychiatric Evaluation of TBI in the Acute Rehabilitation Setting	140
	Bedside Assessment Methods	140
	Neurodiagnostic Methods	142
	Review of Concurrently Prescribed Treatments	144
	Conclusion	145
	References	146
	Miyoshi_Ch11_O.pdf	152
	Neuropsychiatric Aspects of Vascular Cognitive Impairment	153
	Background	154
	Neuropsychiatric Disorders Associated with Cognitive Impairment	154
	Alzheimer’s Disease	154
	Depression	155
	Psychotic Symptoms	155
	Cerebrovascular Diseases Associated with Cognitive Impairment and Neuropsychiatric Conditions	156
	Stroke	156
	Silent Infarcts	158
	White Matter Lesions	158
	Mixed Pathology	160
	Conclusion	161
	References	161
	Miyoshi_Ch12_O.pdf	167
	Neuropsychiatric Complications of Cerebrovascular Disease	167
	Introduction	167
	Mania	168
	Anxiety	169
	Apathy	170
	Disturbance of the Sleep–Wake Cycle	171
	Fatigue	172
	Sexual Dysfunction	173
	Cognitive Performance	174
	Involuntary Emotional Expression Disorder	175
	Irritability	176
	Psychosis	176
	Agitation	177
	Depression	177
	Conclusion	178
	References	178
	Miyoshi_Ch13_O.pdf	181
	Systemic Inflammation and Cognition in the Elderly	181
	Introduction	182
	Background	182
	Inflammation and Alzheimer’s disease	182
	“Inflammaging”	183
	Cross-Sectional Studies	195
	Longitudinal Studies	196
	Discussion	198
	Conclusion	199
	References	199
	Miyoshi_Ch14_O.pdf	202
	Diagnosis and Clinical Relevance of Depression and Apathy in Alzheimer’s Disease	203
	Depression in Alzheimer’s Disease	204
	Diagnosis of Depression in AD	204
	Diagnostic Criteria for Depression in AD	204
	Frequency of Depression in AD	207
	Clinical Correlates of Depression in AD	207
	Conclusion	207
	Apathy in AD	208
	Diagnosis of Apathy in AD	208
	Differential Diagnosis of Apathy in AD	210
	Frequency of Apathy in AD	210
	Clinical Correlates of Apathy in AD	210
	Conclusions	211
	References	211
	Miyoshi_Ch15_O.pdf	214
	Cognitive Decline and Treatment of Alzheimer’s Disease	214
	Treatment of AD	218
	Specific Goals of Treatment	219
	Restoring Neuronal Function	219
	Preventing Synapse and Cell Death	219
	Treatment of the Primary Cognitive Symptoms	219
	Cholinergic Agents	220
	Acetylcholine Precursors	220
	Acetylcholinesterase Inhibitors	220
	Glutamate Regulators	221
	Antioxidants	221
	Antiinflammatory Drugs	222
	Estrogen Replacement Therapy	223
	Neurotrophic Factors	224
	Treatment of Secondary Noncognitive Symptoms	224
	New Nonpharmacological Possibilities of Treatment	225
	References	225
	Miyoshi_Ch16_O.pdf	228
	Alzheimer’s Disease in Japan: Current Situation and Issues of the Care for Persons with Dementia	228
	Introduction	228
	Early Detection and Diagnosis	229
	Supporting the Human Rights of Persons with Dementia	233
	Issues for the Future	234
	References	235
	Miyoshi_Ch17_O.pdf	236
	AD-FTLD Spectrum: New Understanding of the Neurodegenerative Process from the Study of Risk Genes	236
	Genes for AD and FTLD	238
	Progranulin and TDP-43	240
	Copy Number Variation, miRNA, and Neurodegeneration	241
	AD-FTLD Spectrum	242
	References	244
	Miyoshi_Ch18_O.pdf	247
	Dementia with Lewy Bodies	247
	Introduction	247
	Pathology and Etiology	248
	Clinical Features	249
	Investigations	250
	Diagnostic Criteria	251
	References	252
	Miyoshi_Ch19_O.pdf	255
	Dementia with Lewy Bodies and Parkinson Disease with Dementia Within the Spectrum of Lewy Body Disease	255
	Introduction	256
	History of PD and DLB	256
	DLB and PDD Within the Spectrum of Lewy Body Disease	257
	References	258
	Miyoshi_Ch20_O.pdf	260
	Clinicopathological Characterizationof Frontotemporal Lobar Degeneration	260
	Introduction	260
	Pick Disease	263
	FTLD-LDH	264
	FTLD-MND	265
	Comments	267
	References	268
	Miyoshi_Ch21_O.pdf	270
	Diffuse Neurofibrillary Tangles with Calcification	270
	Introduction	271
	Case Presentation	271
	Epidemiology of DNTC	273
	Characteristics of Clinical Symptoms	273
	Pathological Characteristics	274
	NFTs	274
	Characteristics of Degenerative Tau Protein	275
	Electron Microscopy Findings	275
	Calcification	275
	Cerebrovascular Lesions	276
	Lewy Body Pathology	276
	Conclusion	276
	References	276
	Miyoshi_Ch22_O.pdf	278
	Ayahuasca: Current Interest in an Ancient Ritual	279
	Introduction	279
	Description of an Ayahuasca Ceremony	281
	Conclusions	283
	References	284
	Miyoshi_Ch23_O.pdf	285
	The Molecular Genetics of Suicide	285
	Introduction	285
	Molecular Genetics of Suicide	287
	Conclusion	294
	References	294
	Miyoshi_Ch24_O.pdf	296
	Brief History and Current Status of the International Neuropsychiatric Association	297
	Introduction	297
	The Beginning: The First Congress in Seville	298
	The Reorganization: The Second Congress in Toronto	300
	The Springboard: The Third Congress in Kyoto	302
	The Jump: The Fourth Congress in Buenos Aires	303
	The Collaborations: The Fifth Congress in Athens	304
	The Widening: The Sixth Congress in Sydney	306
	The Latest: The Seventh Congress in Cancun	307
	Regional Activities	308
	The Coming INA Meetings	308
	Current Status of the INA	308
	Officers and INA Office	308
	Executive Committee	309
	International Committee	309
	Awards	310
	Journal	310
	Relationships to National Neuropsychiatric Associations	310
	Future Direction	311
	Miyoshi_Ch25_O.pdf	312
	Core Curriculum in Neuropsychiatry of the International Neuropsychiatric Association*	312
	Background	313
	Goals of the Training Program	313
	Structure of the NP Training Program	314
	Objectives	315
	Attitude Objectives	315
	Knowledge Objectives	315
	Skills Objectives	318
	A Survey of Required Competencies in Neuropsychiatry	319
	Core Skills Module	320
	Specific Competencies	320
	Knowledge Base in Neuroscience	320
	Clinical Skills in Neuropsychiatry	320
	Critical Thinking in Neuropsychiatry: Research and Scholarship	324
	Specific Modules	324
	Module 2.1: Cognitive Disorders	324
	Specific Competencies	324
	Diagnostic Techniques	325
	Be familiar with the main principles involved in the management and treatment of cognitive disorders and of dementias	325
	How Taught	326
	How Assessed	326
	Module 2.2: Seizure Disorders	326
	Specific Competencies	326
	Module 2.3: Movement Disorders	328
	Specific Competencies	328
	Suggested Learning Methods	328
	Suggested Assessment Method: Clinic Logbook	329
	Module 2.4: Traumatic Brain Injury	329
	Clinical Settings	329
	Specific Competencies	329
	Suggested Learning Methods	329
	Module 2.5: Secondary Psychiatric Syndromes and Delirium	330
	Clinical Settings	330
	Specific Competencies	330
	Suggested Learning Methods	330
	Module 2.6: Substance-Induced Neuropsychiatric Syndromes	330
	Clinical Settings	330
	Specific Competencies	330
	Suggested Learning Methods	331
	Module 2.7: Attentional and Dysexecutive Syndromes (Including Adult ADHD)	331
	Clinical Settings	331
	Specific Competencies	331
	Suggested Learning Methods	331
	Module 2.8: General Hospital Liaison Neuropsychiatry	332
	Key Competencies	332
	Learning and Assessment Methods	332
	Module 2.9: Developmental Neuropsychiatry	333
	Preamble	333
	Skills in Developmental Neuropsychiatry	334
	Specific Competencies	334
	Learning and Assessment Methods	335
	Module 2.10: Sleep Disorders	336
	Specific Competencies	336
	Diagnostic Techniques	337
	Management	337
	Suggested Learning Methods	337
	Suggested Assessment Methods	338
	Module 2.11: Rehabilitation Neuropsychiatry	338
	Clinical Settings	338
	Knowledge	338
	Skills	338
	Learning and Assessment Methods	339
	Module 2.12: Forensic Neuropsychiatry	339
	Key Competencies	339
	Learning and Assessment Methods	340
	Recommended Reading	340
	Miyoshi_Index_O.pdf	342